Bacitracin (Banocin Powder) is a polypeptide antibiotic which inhibits bacterial cell wall synthesis. It is especially active against gram-positive (Streptococcus spp./including beta-hemolytic streptococcus/, Staphylococcus spp.) and some gram-negative microorganisms. Resistance to bacitracin is rare.
Neomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis. It is active against gram-positive and gram-negative bacteria.
By using a combination of the two antibiotics a wide spectrum of action of the drug and synergistic effect against a number of microorganisms, such as staphylococci, are achieved.
How to Use
- The drug is applied thinly to the affected areas 2-4 times per day.
- In case of burns of more than 20% of the body surface the powder should be applied not more than 1 time a day, particularly in the case of loss of kidney function (since absorption of the active ingredient is possible).
- When applied topically, neomycin dose should not exceed 1 g per day (corresponding to 200 g of powder) for 7 days. During the repeated treatment the maximum dose should be not more than 100 g.